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Contraindications Bactroban Cream is contraindicated in patients with known hypersensitivity to mupirocin or any of the excipients of Bactroban Cream. Bactroban cream is often recommended to be applied three times per day for 10 days on infected traumatic skin conditions. You may cover the treated area with a bandage. After the lesions have healed you could try waxing. BACTROBAN ointment is for use on your skin only BACTROBAN cream contains mupirocin (2% w/w) as the active ingredient. Bactroban cream and ointment contain mupirocin, which acts as an antibacterial medicine. , board certified, and available by text or video. The product is white or off-white and contains the active ingredient mupirocin. Mupirocin belongs to a group of medicines called Antibiotics. A topical antibiotic cream, mupirocin (Bactroban®), has been effective at reducing bacterial colonization in the nostrils. 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Apply approximately one-half of the ointment from the single-use tube into 1 nostril and the other half into the other nostril twice daily (morning and evening) for 5 days. The cream better on dry skin because it gets absorbed with no residual discomfort of "vaseline" on the skin. It is applied twice daily for a week and is repeated every 6 months. Is it ok to use bactroban (mupirocin) cream in nose, not the ointment? Bactroban ointment is the most common form used to treat impetigo. Certain topical antibiotics are also given in the form of shampoo and body wash to treat conditions such as dandruff creams and ointments like Diprogenta (betamethasone + gentamycin), milder steroid ointments like Elomet (mometasone) and even milder ones like Efficort (hydrocortisone aceponate). • After application, close the nostrils by pressing together and releasing the sides of the nose repetitively for approximately 1 minute Clean and dry the affected area first. 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