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Neosporin is available over the counter, while Bactroban requires a prescription. If you are pregnant or planning pregnancy. Bactroban is a topical antibiotic used to treat various skin infections, including impetigo – a bacterial disease on the skin that's caused by a bacteria in the Staphylococcus family. If this medicine gets in your eyes, nose, or mouth, rinse with water. BACTROBAN nasal ointment, 2% is supplied in single-use 1‑gram tubes. Bactroban Nasal Ointment - Clinical Pharmacology Pharmacokinetics. Com There will be nothing comparable to Bactroban available over the counter. Bactroban and Neosporin are both topical antibiotic ointments but contain different medications. Clean and dry the affected skin area. BACTROBAN Nasal is a white to off-white ointment that contains 2. The inactive ingredients are paraffin and a mixture of glycerin esters (SOFTISAN ® 649). 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